Endocrine Abstracts

Context: Gap junction intercellular communication (GJIC) and its constructed protein Connexin (Cx) participates in cell apoptosis and tumorigenesis. Our clinical studies demonstrated that a levonorgestrel (LNG)-releasing intrauterine system can reverse atypical endometrial hyperplasia.Objective: This study assesses whether LNG exerts anti-proliferation effects on human endometrial cells through changes in the GJIC function and Cx43 expression.<p clas...

Objective: For women with polycystic ovary syndrome (PCOS) weight gain and obesity exacerbate insulin resistance and increase the risk of type 2 diabetes and cardiometabolic diseases. The PCOS Phenotype in Unselected Populations (P-PUP) study includes individual participant data (IPD) from eleven well characterised, multiethnic and unselected populations globally. The aim of this study was to assess risk of obesity in women with and without PCOS according to ethnicity and age....

Background: Hirsutism, characterized by the male pattern distribution of terminal hair in females due to elevated androgen levels, is a diagnostic feature for polycystic ovary syndrome (PCOS), assessed by the modified Ferriman-Gallwey (mFG) score. The 2023 international PCOS guideline suggests an mFG score of 4-6 for hirsutism detection. However, the lack of universally applicable cut-offs in diverse populations necessitates further research. Therefore, this study aimed to def...